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* Amnesic effects: Among benzodiazepines, lorazepam has relatively strong amnesic effects, but patients soon develop tolerance to this with regular use. edit PharmacokineticsLorazepam is highly protein bound and is extensively metabolised into pharmacologically inactive metabolites. Hydrolysis of thee above product forms the desired product lorazepam. Tolerance to benzodiazepine effects develops with regular use. Tell your doctor if you regularly use any of these other medicines. High dose or prolonged parentally administered lorazepam is sometimes associated with propylene glycol intoxication. Lorazepam may also inhibit foetal liver bilirubin glucuronidation, leading to neonatal jaundice. Lorazepam's effects are dose-dependent, meaning the higher the dose, the stronger the effects (and side effects) will be. The higher the dose and the longer the drug is taken for, the greater the risk of experiencing unpleasant withdrawal symptoms. Your doctor may occasionally change your dose to make sure you get the best results from this medication.