Lorazepam is absorbed relatively slowly if given intramuscularly, a common route in restraint situations.

If shown sympathy, even quite crudely feigned, patients may respond solicitously, but they may respond with disproportionate aggression to frustrating cues. FDA pregnancy category D. The anticonvulsant properties of lorazepam and other benzodiazepines may be, in part or entirely, due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. Pure lorazepam is an almost white powder that is nearly insoluble in water and oil. Because of its relative long duration of residual effects (sedation, ataxia, hypotension, and amnesia), lorazepam premedication is best suited for hospital inpatient use. Withdrawal symptoms, including rebound insomnia and rebound anxiety, may occur after only 7 days' administration of lorazepam. Before taking Ativan, tell your doctor if you have any breathing problems, glaucoma, kidney or liver disease, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol. Tell your doctor about any unusual or bothersome side effect. Long-term therapy may lead to cognitive deficits, especially in the elderly, which may only be partially reversible.