Long-term effects of benzodiazepines include tolerance, dependence, a benzodiazepine withdrawal syndrome and cognitive impairments which may not completely reverse after cessation of treatment; however, for most patients, cognitive impairment is not severe.

fda. Withdrawal symptoms include headaches, anxiety, tension, depression, insomnia, restlessness, confusion, irritability, sweating, dysphoria, dizziness, derealization, depersonalization, numbness/tingling of extremities, hypersensitivity to light, sound, and smell, perceptual distortions, nausea, vomiting, diarrhea, appetite loss, hallucinations, delirium, seizures, tremor, stomach cramps, myalgia, agitation, palpitations, tachycardia, panic attacks, short-term memory loss, and hyperthermia. To be sure this medication is not causing harmful effects, your doctor may need to check your progress on a regular basis. Synergistic adverse effects may also occur when lorazepam is administered with other drugs such as opioids or other hypnotics. The concern is that, though relatively nontoxic in themselvesverification needed, benzodiazepines may inadvertently become facilitators of suicidal behaviour. It has a fairly short duration of action (Venable and Aschenbrenner 2009). Longer-term use, up to six months, does not result in further accumulation. Do not use this medication without telling your doctor if you are breast-feeding a baby. drug company Mylan agreed to pay $147 million to settle accusations by the F. Lorazepam was the third-most-common benzodiazepine used outside of prescription in these ED visit statistics.