The intermediate oxime is then reacted with chloracetyl chloride, and upon heterocyclization 6-chloro-2-chlormethyl-4-(2′-chlorophenyl)quinazolin-3-oxide is formed.

Dose requirements have to be individualized, especially in the elderly and debilitated patients in whom the risk of oversedation is greater. 9%), weakness (4. Falls and hip fractures are frequently reported. * Acute intoxication – Lorazepam may interact synergistically with the effects of alcohol, narcotics, or other psychoactive substances. Partial, but incomplete tolerance develops to these impairments. * Surgical premedication – Informed consent that was given only after receiving lorazepam premedication could have its validity challenged later. The higher the dose and the longer the drug is taken for, the greater the risk of experiencing unpleasant withdrawal symptoms. Keep the medication in a secure place where others cannot get to it. The combination also causes synergistic enhancement of the disinhibitory and amnesic effects of both drugs, with potentially embarrassing or criminal consequences. Symptoms of floppy infant syndrome and the neonatal benzodiazepine withdrawal syndrome have been reported to persist from hours to months after birth.