This is because the brain has spare benzodiazepine drug receptor capacity, with single, clinical doses leading only to an occupancy of some 3% of the available receptors.

Dose requirements have to be individualized, especially in the elderly and debilitated patients in whom the risk of oversedation is greater. Food and Drug Administration (FDA) or visit www. The higher the dose and the longer the drug is taken for, the greater the risk of experiencing unpleasant withdrawal symptoms. Lorazepam is used for the short-term treatment of anxiety, insomnia, acute seizures including status epilepticus and sedation of hospitalised patients, as well as sedation of aggressive patients. The drug was developed by President of Research, D. Males and females use benzodiazepines for nonmedical purposes equally. Be careful if you drive or do anything that requires you to be awake and alert. It is also used as adjunct therapy for cyclic vomiting syndrome. Lorazepam is used for the short-term treatment of anxiety, insomnia, acute seizures including status epilepticus and sedation of hospitalised patients, as well as sedation of aggressive patients. In cases of a suspected lorazepam overdose, it is important to establish whether the patient is a regular user of lorazepam or other benzodiazepines, since regular use causes tolerance to develop.