Reaction of the above product with acetic anhydride leads to a Polonovski type rearrangement reaction, giving a 3-acetoxylated benzodiazepine, 7-chloro-1,3-dihydro-3-acetoxy-5-(2′-chlorphenyl)-2H-benzodiazepin-2-one.

Lorazepam is metabolised in the liver by conjugation into inactive lorazepam-glucuronide. Before taking Ativan, tell your doctor if you have any breathing problems, glaucoma, kidney or liver disease, or a history of depression, suicidal thoughts, or addiction to drugs or alcohol. Please note that some may list side effects for the entire benzodiazepine class, not the specific side effect profile for lorazepam. Tolerance to benzodiazepine effects develops with regular use. Lorazepam is absorbed relatively slowly if given intramuscularly, a common route in restraint situations. edit HistoryHistorically, lorazepam is one of the "classical" benzodiazepines. * Suicidality: Benzodiazepines may sometimes unmask suicidal ideation in depressed patients, possibly through disinhibition or fear reduction. Acute delirium is sometimes treated with lorazepam, but as it can cause paradoxical effects, it is preferably given together with haloperidol. that they had raised the price of generic lorazepam by 2600 percent and generic clorazepate by 3200 percent in 1998 after having obtained exclusive licensing agreements for certain ingredients. Amnesic effects cannot be estimated from the degree of sedation present, since the two effects are unrelated.