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The injectable solution comes in 1 mL ampoules containing 2 mg or 4 mg lorazepam. Lorazepam's effects are dose-dependent, meaning the higher the dose, the stronger the effects (and side effects) will be. The marked anticonvulsant properties of lorazepam, and its pharmacokinetic profile, make intravenous lorazepam a reliable agent for terminating acute seizures, but it has relatively prolonged sedation after-effects. The injectable solution comes in 1 mL ampoules containing 2 mg or 4 mg lorazepam. Pure lorazepam is an almost white powder that is nearly insoluble in water and oil. Benzodiazepines, including lorazepam, have been found to increase the risk of falls and fractures in the elderly. Side effects such as sedation and unsteadiness increased with age. Thus the effect of benzodiazepines is to enhance the effects of the neurotransmitter GABA. Although lorazepam is not necessarily better than diazepam at initially terminating seizures, lorazepam is, nevertheless, replacing diazepam as the intravenous agent of choice in status epilepticus. The advantage of switching to diazepam is that dose reductions are felt less acutely, because of the longer half lives (20–200 hours) of diazepam and its active metabolites.